<?xml version="1.0"?>
<record>
  <id>https://homosaurus.org/v4/homoit0002863</id>
  <identifier>homoit0002863</identifier>
  <prefLabel language="en">Leydig cell hypoplasia</prefLabel>
  <prefLabel language="es">Hipoplasia de c&#xE9;lulas de Leydig</prefLabel>
  <altLabel language="en">LCH</altLabel>
  <issued>
    <value>2023-06-28</value>
    <name>xsd:date</name>
  </issued>
  <modified>
    <value>2023-06-28</value>
    <name>xsd:date</name>
  </modified>
  <broader>
    <id>https://homosaurus.org/v4/homoit0000669</id>
    <prefLabel language="en">Intersex variations</prefLabel>
  </broader>
  <narrower>
    <id>https://homosaurus.org/v4/homoit0002879</id>
    <prefLabel language="en">Type 1 Leydig cell hypoplasia</prefLabel>
  </narrower>
  <narrower>
    <id>https://homosaurus.org/v4/homoit0002881</id>
    <prefLabel language="en">Type 2 Leydig cell hypoplasia</prefLabel>
  </narrower>
  <comment language="en">People with Leydig cell hypoplasia (LCH) have XY chromosomes and a genetic insensitivity to luteinizing hormone. LCH can be either complete (known as LCH Type 1) or partial (known as LCH Type 2). Luteinizing hormone is typically responsible for the development of Leydig cells in the testicles and for signaling for those cells to produce androgens like testosterone. Someone with LCH will develop few or no Leydig cells and therefore will produce less testosterone than is typical.</comment>
  <comment language="es">Las personas con hipoplasia de c&#xE9;lulas de Leydig (HCL) tienen cromosomas XY y una insensibilidad gen&#xE9;tica a la hormona luteinizante. La HCL puede ser completa (conocida como HCL tipo 1) o parcial (conocida como HCL tipo 2). La hormona luteinizante suele ser responsable del desarrollo de las c&#xE9;lulas de Leydig en los test&#xED;culos y de indicarles a esas c&#xE9;lulas que produzcan andr&#xF3;genos como la testosterona. Alguien con HCL desarrollar&#xE1; pocas o ninguna c&#xE9;lula de Leydig y, por lo tanto, producir&#xE1; menos testosterona de lo normal.</comment>
</record>
